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Relationship between composite region of interest (ROI) estimates of PS w and PS g. Regression analysis was applied separately to 13‐, 18‐ and 21‐month data and did not reveal any significant trends between PS w and PS g (p > 0.05). The lack of relationship between PS w and PS g indicates that in the rat model and age groups studied, blood–brain barrier (BBB) water exchange and BBB leakage of gadoteric acid occur by different mechanisms
