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. 2024 Sep 30;16(19):3353. doi: 10.3390/cancers16193353

Figure 1.

Figure 1

Evaluation of CD8+ T cells, CXCR3 expression in tumor-infiltrating lymphocytes (TILs), and immune phenotypes via Lunit SCOPE IO, and their correlations. Immunohistochemical evaluation of infiltration of CD8+ T cells and CXCR3 in tumor-infiltrating lymphocytes (TILs). Grade 1, no or low expression; Grade 2, moderate expression; and Grade 3, high expression. Lunit SCOPE IO infers segmentation of the cancer epithelium (green), cancer stroma (blue), and TIL (yellow dot). The definitions of inflamed, immune-excluded, and immune-desert are described in the Methods section (A). The analysis demonstrated that increased CD8+ T cell infiltration was positively associated with increased CXCR3 expression in tumor-infiltrating lymphocytes (TILs) and an inflamed immunophenotype, indicating a favorable immune response (B). Correlations between CD8+ T cells, CXCR3 and immune phenotypes (B). IF, inflamed; IE, immune-excluded; ID, immune-desert.