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. 2024 Oct 1;16(19):3365. doi: 10.3390/cancers16193365

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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An 84-year-old male patient with known pancreatic carcinoma and a pulmonary nodule on the (A) computed tomography (arrow) (courtesy of Prof. Dr. Andreas H. Mahnken, Department of Radiology, University Hospital Marburg) and (B,C) B-mode ultrasound. (C) An ultrasound-guided 18G core needle biopsy of the lung lesion was performed, and histopathological examination confirmed the diagnosis of metastatic pancreatic carcinoma. On contrast-enhanced ultrasound, the lesion demonstrated (D) an enhancement simultaneous with the arrival of the contrast agent in the intercostal artery (arrows), and a marked and homogeneous pattern of enhancement with (E,F) an early decrease of enhancement. (G) The tissue sample (HE staining) showed the infiltrates of a ductal adenocarcinoma consistent with a metastasis of the previously known pancreatic carcinoma. (H) immunohistochemical staining with CD34 was performed, revealing a chaotic pattern consistent with bronchial-arterial neoangiogenesis (×100).