Table 1.
Baseline characteristics: 8q surgain was defined as more than 3 chromosome 8q copies. Four patients had missing data for ciliary body extension. UM: uveal melanoma; AJCC: American Joint Committee on Cancer; LDH: lactate dehydrogenase; MRI: magnetic resonance imaging; ULN: upper limit of normal.
| Variables | All (n = 86) | Chromosome 8q Surgain | p-Value | ||
|---|---|---|---|---|---|
| Absent (n = 46) | Present (n = 40) | ||||
| Age (years) | ≤50 | 36 (42%) | 22 (48%) | 14 (35%) | 0.23 |
| >50 | 50 (58%) | 24 (52%) | 26 (65%) | ||
| Gender | Female | 46 (53%) | 24 (52%) | 22 (55%) | 0.79 |
| Male | 40 (47%) | 22 (48%) | 18 (45%) | ||
| Ocular UM thickness (mm) | ≤20 | 81 (94%) | 43 (93%) | 38 (95%) | 0.76 |
| >20 | 5 (6%) | 3 (7%) | 2 (5%) | ||
| Ocular UM largest basal diameter (mm) | <10 | 56 (65%) | 27 (59%) | 29 (73%) | 0.18 |
| >10 | 30 (35%) | 19 (41%) | 11 (28%) | ||
| AJCC tumor category | T1/2/3 | 52 (60%) | 29 (63%) | 23 (58%) | 0.60 |
| T4 | 34 (40%) | 17 (37%) | 17 (43%) | ||
| Ciliary body extension | Absent | 55 (68%) | 32 (74%) | 23 (61%) | 0.18 |
| Present | 26 (32%) | 11 (26%) | 15 (39%) | ||
| Treatment of ocular UM | I-Disk or Proton beam irradiation | 50 (58%) | 29 (63%) | 21 (53%) | 0.32 |
| Enucleation | 36 (42%) | 17 (37%) | 19 (48%) | ||
| Performance status | 0 | 84 (98%) | 46 (100%) | 38 (95%) | 0.12 |
| 1 | 2 (2%) | 0 (0%) | 2 (5%) | ||
| Disease-free interval (months) | ≤24 | 32 (37%) | 9 (20%) | 23 (58%) | <0.001 |
| >24 | 54 (63%) | 37 (80%) | 17 (43%) | ||
| LDH level | ≤ULN | 34 (92%) | 20 (100%) | 14 (82%) | 0.05 |
| >ULN | 3 (8%) | 0 (0%) | 3 (18%) | ||
| Number of liver lesions in MRI | ≤2 | 56 (65%) | 30 (65%) | 26 (65%) | 0.98 |
| >2 | 30 (35%) | 16 (35%) | 14 (35%) | ||
| Largest lesion size in MRI (mm) | ≤20 | 60 (70%) | 32 (70%) | 28 (70%) | 0.97 |
| >20 | 26 (30%) | 14 (30%) | 12 (30%) | ||
| Largest lesion area in MRI (mm2) | ≤250 | 46 (53%) | 24 (52%) | 22 (55%) | 0.79 |
| >250 | 40 (47%) | 22 (48%) | 18 (45%) | ||
| Type of liver surgery | Coelioscopy | 2 (2%) | 1 (2%) | 1 (3%) | 0.92 |
| Laparotomy | 84 (98%) | 45 (98%) | 39 (98%) | ||
| Capsular miliary disease | Absent | 40 (47%) | 26 (57%) | 14 (35%) | 0.05 |
| Present | 46 (53%) | 20 (43%) | 26 (65%) | ||
| Parenchymal miliary disease | Absent | 70 (81%) | 40 (87%) | 30 (75%) | 0.16 |
| Present | 16 (19%) | 6 (13%) | 10 (25%) | ||
| Major hepatectomy | Absent | 48 (56%) | 26 (57%) | 22 (55%) | 0.89 |
| Present | 38 (44%) | 20 (43%) | 18 (45%) | ||
| Macroscopically resection | Complete (R0/R1) | 80 (93%) | 44 (96%) | 36 (90%) | 0.31 |
| Incomplete (R2) | 6 (7%) | 2 (4%) | 4 (10%) | ||
| Bleeding loss (mL) | >100 | 46 (53%) | 21 (46%) | 25 (63%) | 0.12 |
| ≤100 | 40 (47%) | 25 (54%) | 15 (38%) | ||