Table 5.
Clinical APS domains according to the 2023 ACR/EULAR classification criteria.
| Sidney Criteria N = 93 |
2023 ACR/EULAR Criteria | |||
|---|---|---|---|---|
| YES N = 24 |
NO N = 69 |
p | ||
| D1: Macrovascular (VTE), n (%) | 12 (12.9) | 9 (37.5) | 3 (4.3) | <0.001 |
| - With a high-risk VTE profile | 1 (1.1) | - | 1 (1.45) | 0.58 |
| - Without a high-risk VTE profile | 11 (11.8) | 9 (37.5) | 2 (2.9) | <0.0001 |
| D2: Macrovascular (AT), n (%) | 6 (6.5) | 4 (16.7) | 2 (2.9) | 0.037 |
| - With a high-risk CVD profile | 2 (2.2) | - | 2 (2.9) | 0.98 |
| - Without a high-risk CVD profile | 4 (4.3)) | 4 (16.7) | - | 0.004 |
| D3: Microvascular, n (%) | - | - | - | - |
| D4: Obstetric, n (%) | 74 (79.6) | 11 (45.8) | 63 (91.3) | <0.001 |
| - ≥3 pre-fetal Abortion (<10 w) and/or fetal (10 w 0 d–5 w 6 d) deaths | 44 (47.3) | 2 (8.3) | 42 (60.9) | <0.0001 |
| - Fetal (16 w 0 d–3 w 6 d) deaths in the absence of PEC or PI | 20 (21.5) | 1 (4.2) | 19 (27.5) | 0.03 |
| - Preeclampsia with severe features (<34 w 0 d) or PI with severe features (<34 w 0 d) with/without fetal death | 8 (8.6) | 6 (25) | 2 (2.9) | 0.004 |
| - Preeclampsia with severe features (<34 w 0 d) and PI with severe features (<34 w 0 d) with/without fetal death | 2 (2.2) | 2 (8.3) | - | 0.11 |
| D5: Cardiac valve, n (%) | - | - | - | - |
| D6: Thrombocytopenia, n (%) | 12 (12.9) | 11 (45.8) | 1 (1.4) | <0.001 |
VTE: venous thromboembolism; AT: arterial thrombosis; CVD: cardiovascular disease; PI: placental insufficiency; w:weeks; d: days.