Figure 7.

Inhibition of TGF-β-induced expression of pro-inflammatory and atherogenic genes in HAECs by Oxy210. HAECs were pretreated with Oxy210 (5 μM) in M199 containing 1% FBS for 6 h and then treated with rhTGF-β1 (10 ng/mL) in the absence or presence of Oxy210. After 48 h, RNA was extracted and analyzed by Q-RT-PCR for the expression of the genes as indicated and normalized to GAPDH expression. Data from a representative experiment are reported as the mean of triplicate determinations ± SD (## p < 0.01 vs. TGF-β; ** p < 0.01 vs. control).