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[Preprint]. 2024 Dec 21:2024.10.06.616871. Originally published 2024 Oct 7. [Version 2] doi: 10.1101/2024.10.06.616871

FIGURE 4.

FIGURE 4

Dh31/Dh44-induced changes in spike pattern and KCa channel conductance. (a) Quantification of spike frequency adaptation with ISIx/ISI1 ratio for Dh31, Dh44, Dh31 and Dh44, Dh31/Dh44/apamin, and Dh31/Dh44/cadmium (N=5). (b-d) Quantification of spike irregularity of CV, LV, and CV2 for varying conditions with (+) and without (−) Dh31, Dh44, apamin, and cadmium (N=6 each). (e) Current traces (at +30mV voltage-step) of control, Dh31, Dh44, Dh31/Dh44, SLOB RNAi control, and SLOB RNAi with Dh31/Dh44. (f) I-V relationship of KCa conductance and peak amplitude of KCa for control, Dh31, Dh44, and Dh31/Dh44 (n=4 each), as well as for SLOB RNAi control and SLOB RNAi with Dh31/Dh44 (n=3 each). (g) Quantification of Peak Amplitude of KCa for varying conditions with (+) and without (−) Dh31, Dh44 (n=4 each), and SLOB RNAi conditions (n=3 each). Two-way ANOVA with multiple comparisons was used. A p-value < 0.05 was considered statistically significant, with asterisks indicating p-values as follows: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.