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The stable p21 mutants induce the expression of senescence-associated genes. (A–F) the mRNA levels of several genes in wild-type and p21edited HEK293. (G–L) mRNA levels of the same set of genes in wild-type HeLa and p21–5A HeLa cells. Cells were either untreated or exposed to 10 Gy (X-ray) radiation. Error bars indicate the standard deviation or standard error of the mean. * p < 0.1, ** p < 0.01 and *** p < 0.001.
