Table 4.
Lung Function Parameters, Controller Selection, and FAO Severity of Enrolled Participants
| Variable | Variableotal | Normal FEF25-75%/Non-FAO | Low FEF25-75%/ Non-FAO | Low FEF25-75%/ FAO | P |
| n=312 | n=87 | n=83 | n=142 | ||
| Spirometric measures | |||||
| FEV1 z-score | −1.76 [−2.96;–0.58] | −0.03 [−0.64;0.62] | −1.63 [−2.25;–1.10]* | −3.05 [−3.99;–2.08]*# | <0.001 |
| FVC z-score | −0.81 [−1.82;0.13] | −0.02 [−0.83;0.66] | −1.38 [−2.09;–0.58]* | −1.05 [−1.89;–0.15]* | <0.001 |
| FEV1/FVC z-score | −1.50 [−3.46;–0.60] | 0.14 [−0.56;0.62] | −1.17 [−1.45;–0.80]* | −3.57 [−4.20;–2.59]*# | <0.001 |
| FEF25-75% z-score | −1.60 [−2.61;–0.62] | −0.08 [−0.38;0.45] | −1.40 [−1.72;–1.11]* | −2.68 [−3.28;–2.14]*# | <0.001 |
| FEF25-75%/FVC ratio | 41.0 [25.9;59.5] | 73.5 [60.5;90.6] | 46.4 [41.1;54.9]* | 24.8 [17.8;31.7]*# | <0.001 |
| Controller selection | |||||
| ICS | 273 (87.5) | 65 (74.7) | 79 (95.2)* | 129 (90.8)* | <0.001 |
| LABA | 268 (85.9) | 63 (72.4) | 78 (94.0)* | 127 (89.4)* | <0.001 |
| LAMA | 71 (22.8) | 3 (3.45) | 12 (14.5)* | 56 (39.4)*# | <0.001 |
| LTRA | 159 (51.0) | 46 (52.9) | 41 (49.4) | 72 (50.7) | 0.896 |
| FAO severity | |||||
| Mild | 33 (23.2) | ||||
| Moderate | 19 (13.4) | ||||
| Moderately severe | 18 (12.7) | ||||
| Severe | 36 (25.4) | ||||
| Very severe | 36 (25.4) |
Notes: Categorical variables were presented as count (percentage), continuous variables were presented as median (IQR). Severity of FAO were stratified using FEV1 z-score. *Significantly different from Normal FEF25-75%/Non-FAO. #Significantly different from Low FEF25-75%/Non-FAO. See Figure 2 legend for expansion of other abbreviations.
Abbreviations: ICS, inhaled corticosteroids; LABA, long-acting beta-2 agonist; LAMA, long-acting muscarinic antagonist; LTRA, leukotriene receptor antagonist.