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. 2024 Oct 6;13(19):1656. doi: 10.3390/cells13191656
CDK cyclin-dependent kinase
CDKI cyclin-dependent kinase inhibitor
EGFR epidermal growth factor receptor
VEGFR vascular endothelial growth factor receptor
FDA the Food and Drug Administration of the United States
FGFR fibroblast growth factor receptor
HER2 human epidermal growth factor receptor-2
NSCLC non-small cell lung cancer
PDGFR platelet-derived growth factor receptor
ATP adenosine triphosphate
HDAC Histone deacetylase
IC50 inhibitory concentration
GI50 half-maximum growth inhibition
PDB Protein Data Bank
SAR structure-activity relationship
WHO World Health Organization
M phase mitosis phase
RTK receptor tyrosine kinase
MOA Mechanism of action
Cancer Cell Lines Explanation
A375 melanoma
A431 squamous
MDA-MB231 breast
Colo205 colon
HCT116 colon
A549 lung
MCF-7 breast
PC3 prostate
HepG2 liver
MDA-MB-468 breast
T-47D breast
HeLa cervical
K-562 leukemia
A2780 ovarian
HL60 leukemia
HT-29 colon
MOLT-4 lymphoblastic leukemia
H460 lung
SMMC77 liver
MV4-11 leukemia
SKOV3 ovarian
WI-38 lung
Panc-1 pancreas
PaCa-2 pancreas
BxPc-3 pancreas
NCIH522 lung
HCT-15 colon
RKO colon
SW480 colon
DLD1 colon
LO2 liver
PC-9 lung
HOP92 lung
SNB-75 brain
DU-145 brain