TABLE 3.

Substitution rate estimates based on the number of synonymous substitutions and ML branch lengths

Viruses compared	dS (mean ± SD)	Divergence of host rodents (millions of yrs ago)	No. of synonymous substitutions/site/yr	Branch length	Divergence of host rodents (millions of yrs ago)	No. of nucleotide substitutions/site/yr
JPN PUUV-like vs PUUV	110 ± 10	1–3	3.7 × 10−7–1.1 × 10−6	0.215–0.349	1–3	0.7 × 10−7–3.5 × 10−7
TULV vs PUUV	185 ± 36	3.5–6	2.5 × 10−7–2.2 × 10−6	0.823–1.689	3.5–6	1.4 × 10−7–4.8 × 10−7
HTNV vs PUUV	275 ± 48	10	2.3 × 10−7–3.3 × 10−7	10.37	10	1.1 × 10−6
HTNV vs TULV	222 ± 36	10	1.9 × 10−7–2.6 × 10−7