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General characteristics at the end of the study. (a) Body weight (BW); (b) Blood glucose (BG); (c) Heart weight (HW); (d) The ratio of heart weight to body weight (HW/BW). C, Control (n = 17); D, Diabetic (n = 17); SV, Sacubitril/valsartan-treated diabetic (n = 16); and V, Valsartan-treated diabetic (n = 15). ****, p < 0.0001 compared to control; #, p < 0.05; ###, p < 0.001 compared to diabetic.
