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In vivo echocardiography parameters of systolic function. (a) % EF, ejection fraction; (b) % FS, fractional shortening. C, Control (n = 8); D, Diabetic (n = 7); SV, Sacubitril/valsartan-treated diabetic (n = 7); and V, Valsartan-treated diabetic (n = 9). ****, p < 0.0001 compared to control. ##, p < 0.01; ####, p < 0.0001 compared to diabetic.
