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Isoprenaline- and forskolin-mediated contractile responses. (a) Cumulative concentration–response curve. (b) Emax, Efficacy. C, Control (n = 8); D, Diabetic (n = 7); SV, Sacubitril/valsartan-treated diabetic (n = 8); and V, Valsartan-treated diabetic (n = 6). *, p < 0.05 compared to control. (c) Contraction response at 3 µM forskolin (% of control). C, Control (n = 7); D, Diabetic (n = 7); SV, Sacubitril/valsartan-treated diabetic (n = 5); and V, Valsartan-treated diabetic (n = 5).
