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. 2024 Oct 2;25(19):10617. doi: 10.3390/ijms251910617

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CL 316,243-mediated relaxation responses. (a) LVDP, left ventricle developed pressure; (b) % relaxation response at 10⁻⁸ M CL 316,243; (c) dP/dt_max (% basal values), rate of contraction; (d) dP/dt_min (%basal values), rate of relaxation. C, Control (n = 6); D, Diabetic (n = 6); SV, Sacubitril/valsartan-treated diabetic (n = 5); and V, Valsartan-treated diabetic (n = 5).