Table 3.
In vivo echocardiography parameters.
| C (n = 8) | D (n = 7) | SV (n = 7) | V (n = 9) | |
|---|---|---|---|---|
| IVSd (mm) | 1.91 ± 0.58 | 2.31 ± 0.38 | 1.83 ± 0.25 # | 1.78 ± 0.25 ## |
| IVSId (mm/kg) | 4.30 ± 1.37 | 6.94 ± 1.04 ** | 5.64 ± 0.65 # | 5.73 ± 1.13 # |
| LVIDd (mm) | 5.49 ± 0.67 | 5.06 ± 0.91 | 5.21 ± 1.12 | 4.92 ± 0.50 |
| LVIDId (mm/kg) | 12.26 ± 1.55 | 15.33 ± 3.35 * | 16.46 ± 5.39 | 15.84 ± 2.52 |
| LVPWd (mm) | 2.35 ± 1.90 | 2.20 ± 0.72 | 1.89 ± 0.29 | 2.01 ± 0.66 |
| LVPWId (mm/kg) | 5.05 ± 3.47 | 6.51 ± 1.65 | 5.82 ± 0.87 | 6.47 ± 2.30 |
| IVSs (mm) | 2.93 ± 0.83 | 2.76 ± 0.51 | 2.17 ± 0.45 # | 2.17 ± 0.35 # |
| IVSIs (mm/kg) | 6.50 ± 1.69 | 8.31 ± 1.65 | 6.76 ± 1.65 | 6.96 ± 1.37 |
| LVIDs (mm) | 3.01 ± 0.21 | 3.71 ± 0.51 ** | 3.43 ± 0.78 | 3.10 ± 0.21 ## |
| LVIDIs (mm/kg) | 6.75 ± 0.72 | 11.27 ± 2.20 **** | 10.86 ± 3.80 | 9.96 ± 1.16 |
| LVPWs (mm) | 2.93 ± 0.49 | 2.80 ± 0.66 | 2.56 ± 0.54 | 2.79 ± 0.60 |
| LVPWIs (mm/kg) | 6.57 ± 1.36 | 8.33 ± 1.43 * | 7.80 ± 1.09 | 9.00 ± 2.29 |
| CO (mL/dk) | 101.25 ± 39.07 | 52.86 ± 29.84 * | 60.14 ± 28.64 | 51.11 ± 13.64 |
| CI (mL/dk.g) | 0.23 ± 0.09 | 0.16 ± 0.09 | 0.19 ± 0.11 | 0.16 ± 0.05 |
| EF (%) | 81.60 ± 4.20 | 57.27 ± 7.21 **** | 69.56 ± 5.84 ## | 72.69 ± 3.72 #### |
| FS (%) | 45.01 ± 4.54 | 26.04 ± 4.60 **** | 34.34 ± 4.31 ## | 36.63 ± 3.11 #### |
IVSd, interventricular septum thickness at end diastole; IVSId, interventricular septum thickness at end diastole index; LVIDd, left ventricular internal dimension at end diastole; LVIDId, left ventricular internal dimension at end diastole index; LVPWd, left ventricular posterior wall thickness at end diastole; LVPWd, left ventricular posterior wall thickness at end diastole index; IVSs, interventricular septum thickness at end systole; IVSIs, interventricular septum thickness at end systole index; LVIDs, left ventricular internal dimension at end systole; LVIDIs, left ventricular internal dimension at end systole index; LVPWs, left ventricular posterior wall thickness at end systole; LVPWIs, left ventricular posterior wall thickness at end systole index; CO, cardiac output; CI, cardiac index; % EF, ejection fraction; % FS, fractional shortening; C, Control (n = 8); D, Diabetic (n = 7); SV, Sacubitril/valsartan-treated diabetic (n = 7); and V, Valsartan-treated diabetic (n = 9). *, p < 0.05; **, p < 0.01; ****, p < 0.0001 compared to control. #, p < 0.05; ##, p < 0.01; ####, p < 0.001 compared to diabetic.