Table 9.
Quantified Parameter | Score | ||||
---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |
Damage Extent | |||||
Focal Lesions | Diffuse Lesions | ||||
Mesangial Changes | |||||
Hypercellularity | Absent | Low min 3 cells into one mesangial area |
Moderate min 3 cells in 2 mesangial areas |
Marked min 3 cells in >2 mesangial areas |
|
Matrix Proliferation | Absent | Low deposits in one mesangial area |
Moderate deposits in 2 mesangial areas |
Marked deposits in >2 mesangial areas |
|
Fibrinoid Necrosis | Absent | Absent | Absent | Present | |
Sclerosis | Absent | Absent | Absent | Absent | Present |
Glomerular Capillary Changes | |||||
Absent | 2–3 inflammatory cells in 2 capillaries | Endocapillary hypercellularity | Capillary necrosis, hyaline trombi |
Glomerular collapse | |
Basement Membrane Changes. | |||||
Absent | “Double contour” | “Wire loops” | Transformation into sclerosis | ||
Segmental Sclerosis | |||||
Absent | Present in <50% of RCs | Present in >50% of RCs | Present in >75% of RCs | ||
Crescent | |||||
Absent | Cellular | Fibro-cellular | Fibrillar | ||
Global Sclerosis | |||||
Absent | Present in <50% of RCs | Present in >50% of RCs | Present in >75% of RCs | Present in 90–100% of RCs |