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. 2024 Sep 30;25(19):10529. doi: 10.3390/ijms251910529

Figure 2.

Figure 2

Ethanol withdrawal signs and binge-like ethanol drinking in the dark after 72 h of abstinence. (A,B) Global EWS (sum of somatic withdrawal scores across the five behavioral signs) measured between 2 and 72 h after the removal of the 20% v/v ethanol solution, in water and AO-treated rats, respectively. (C) Average of global EWS scores measured at the 6th and the 24th hours of ethanol removal. (D) 20% v/v ethanol consumption (g/kg/2 h) on the 4th day of the drinking in the dark test in water- and AO-treated Ctrl (n = 10), UMS (n = 11), IEI (n = 11), and IEI/UMS (n = 11) groups. The values represent the mean ± SEM. (A,B): a p < 0.05, aaa p < 0.001, IEI vs. Ctrl; bbb p < 0.001, Ctrl vs. IEI/UMS; ccc p < 0.001, UMS vs. IEI/UMS. (C,D): a p < 0.05, aa p < 0.01, aaa p < 0.001 compared with Ctrl; bb p < 0.01, bbb p < 0.001 compared with IEI; c p < 0.05, cc p < 0.01, ccc p < 0.001 compared with UMS. δδδ p < 0.001 AO effect, according to RM 3-way or 2-way ANOVA, followed by Tukey’s test. AO: Argan oil, EWS: Ethanol withdrawal signs.