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Possible mechanisms proposed for the “therapeutic” effects of AO against adolescent binge-like/mild stress exposure. Our study suggests that virgin AO supplementation during voluntary ethanol consumption, exerted addictolytic-like effects in IEI/UMS rats, mediated in part by normalizing plasma CORT levels, reducing brain neuronal loss while upregulating BDNF levels and oxidative stress imbalance in the amygdala.
