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The effect of advancing age on energy homeostasis in male C56BL/6J mice. Panel (A): heat; Panel (B): RER; Panel (C): activity; Panel (D): caloric intake. Following a significant 2 × 2 (age × light phase) ANOVA, the Tukey post hoc test was used to locate statistically significant differences. * Significant age effect, # significant lighting phase effect, + significantly different from all other groups with similar light phase by Tukey post hoc test. N = 7–10 mice per group.
