FIG. 3.

2-18 and 56 are original isolates with low and high replicative efficiencies, respectively. 2-18P⁵⁶, 2-18SP⁵⁶, 2-18TP⁵⁶, 2-18RNaseH⁵⁶, and 2-18RT⁵⁶ are 2-18 HBV chimeric genomes in which the full-length P gene and functional regions of the P gene (spacer, TP, RNase H, and RT) were replaced with their counterparts from 56. Intensity of hybridization signal was measured by densitometry, and the relative intensity of these samples is indicated at the bottom. Lane M, molecular size standards.