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Representative SRM chromatograms of a blank DBS sample (a), a blank DBS sample containing the ISs (b), an LLOQ sample (c), and DBS samples from patients treated with abemaciclib (d), palbociclib (e), and ribociclib (f). The measured concentrations were 110 ng/mL for abemaciclib, 86 ng/mL for M20, 104 ng/mL for M2, and 84 ng/mL for letrozole, 58 ng/mL for palbociclib and 50 ng/mL for letrozole, 653 ng/mL for ribociclib, and 114 ng/mL for letrozole.
