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. 2024 Oct 15;25:273. doi: 10.1186/s13059-024-03411-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Example of the rs2395178-cg00886432 locus and colocalization results with type I diabetes (T1D). A An association plot for the rs2395178-cg00886432 locus, separated into individuals with high and low abundance of CD8+ T-cells (above and below the median, respectively). The y axis shows methylation beta-values, while the x axis shows genotypes. B LocusZoom plots for the association of rs2395178 (mapped to HLA-DRA) with phenotypes/molecular traits. Panels illustrate the association of the SNP with GWAS T1D, cg00886432 meQTL signal in CD8+ T-cells, CD4+ T-cells, B cells, natural killer cells, monocytes, and granulocytes. The genetic variant rs2395178 was identified as a colocalized SNP between T1D and cg00886432 meQTL signal in CD8+ T-cells (posterior probability for colocalization (PPFC) is shown)