Figure 3.

Retrograde endocannabinoid signaling is altered by linalool or 2-phenylethanol stimulus. (A) Schematic diagram of the experimental design for RNA-sequencing analysis in the hippocampus of linalool- or 2-phenylethanol-exposed mice. (B,C) Volcano plots of differentially expressed genes in the hippocampus of linalool-treated mice over control mice (B) and 2-phenylethanol-treated mice over control mice (C). (D,E) Venn maps of downregulated genes (D) and upregulated genes (E) between linalool- and 2-phenylethanol-treated mice. (F,G) Enriched KEGG pathways of dysregulated genes in linalool- (F) and 2-phenylethanol-treated (G) mice. (H) A table of dysregulated genes involved in retrograde endocannabinoid signaling for linalool- or 2-phenylethanol-exposed mice. The green color labels downregulated genes and the red color labels upregulated genes.