Table 3.
Features selected based on ML models trained on targeted proteomics.
| Model | Features Selected |
|---|---|
| Urine Models predicting PHVD | |
| Urine IVH | DEFB4A; GA at birth |
| Urine IVHp | GA at birth; TDGF1 |
| Urine PHVD | – a |
| Urine IVH_IVHp | RBKS; GA at birth; PPP3R1 |
| Urine IVH_IVHp_PHVD | RBKS; GA at birth; CD33; SNCG; PP3R1 |
| Serum Models predicting PHVD | |
| Blood IVH | PPP3R1; GA at birth |
| Blood IVHp | FUT8; GA at birth; RBKS |
| Blood PHVD | KLB; GA at birth; PAEP; PTS; AOC1; ISLR2; NXPH1; IVHgrade_MAX; VSTMT |
| Blood IVH_IVHp | GA at birth; PPP3R1; FUT8 |
| Blood IVH_IVHp_PHVD | DPEP2; GA at birth |
| Urine Models predicting survival | |
| Urine IVH | GA at birth; HSP90B1; KIRREL2 |
| Urine IVHp | – a |
| Urine PHVD | FGFR2; GA at birth |
| Urine IVH_IVHp | GA at birth |
| Urine IVH_IVHp_PHVD | – a |
| Urine PHVDp1 | – a |
| Urine PHVDp2 | – a |
| Urine PHVDp3 | – a |
| Urine 28 days of life | – a |
| Urine 32 weeks | – a |
| Urine term-equivalent age | Not able to perform ML |
| Serum Models predicting survival | |
| Blood IVH | PRTFDC2; GA at birth; AKT1S1; FKBP5; SNCG; DPEP2 |
| Blood IVHp | FGFR2; GA at birth; IL15; FKBP5; DPEP2; CLSTN1; IFNL1; RBKS |
| Blood PHVD | GPNMB; DSG3; FGFR2; NEFL; IL15; CDH15; ADAM15; GA at birth; KIR2DL3; PLA2G10 |
| Blood IVH_IVHp | DPEP2; GA at birth; IL15; GSTP1; COL4A3BP; PRTFDC1; SNCG |
| Blood IVH_IVHp_PHVD | GA at birth; DSG3 |
| Blood PHVDp1 | FGFR2; ADAM15; NEFL; PLA2G10; IL15; CDH15; BST2; FCAR; GA at birth |
| Blood PHVDp2 | GA at birth; TNFRSE13C; PAEP |
| Blood PHVDp3 | IFNL1; SNCG; GA at birth; TDGF1; ADGRB3; IL32 |
| Blood 28 days of life | – a |
| Blood 32 weeks | – a |
| Blood term-equivalent age | – a |
| Applied thresholds for the models: AUC-ROC ≥ 0.7; Sensitivity ≥ 0.6 and Selectivity ≥ 0.6.Features selected from models passing thresholds had to display a relative variable importance measure ≥ 50. | |
a Indicates, that no model passed the threshold for evaluation. Abbreviations: GA, gestational age; IVH, interventricular hemorrhage; PHVD, posthemorrhagic ventricular dilatation; IVHgrade_MAX, maximum degree of IVH.