Table 1.
Large trials assessing the connection of NAFLD and symptomatic CAD.
| First Author | Year of Publication | Number of Patients | NAFLD and CAD Diagnostic Method | Results |
|---|---|---|---|---|
| Thévenot [68] | 2022 | 189 | Non-invasive fibrosis tests, Fibroscan and coronary angiography | 5% of patients with documented CAD had NAFLD. |
| Hsu [33] | 2021 | 1502 | Abdominal ultrasonography and cardiac computed tomography | NAFLD severity is associated with coronary artery atherosclerosis burden, and steatosis severity correlated with the risk of presence of coronary plaques. |
| Fiorentino [69] | 2020 | 1254 | Abdominal ultrasonography and coronary angiography | NAFLD independently associated with an increased risk of having CVD in patients with glucose disturbances. |
| Langroudi [70] | 2018 | 264 | Abdominal ultrasonography and cardiac computed tomography | NAFLD may NOT be associated with atherosclerosis of coronary arteries and its severity in non-diabetic patients. |
| Sinn [67] | 2017 | 4731 | Abdominal ultrasonography and cardiac computed tomography | NAFLD was significantly associated with the development of CAD. |
| Ishiba [71] | 2016 | 698 | Abdominal and cardiac computed tomography | The progression of arteriosclerosis and that of liver fibrosis may be associated in NAFLD patients. |
| Osawa [72] | 2015 | 414 | Abdominal and cardiac computed tomography | Diagnosis of NAFLD may be important when assessing the risk of CAD. |
| Wong [73] | 2015 | 612 | Abdominal ultrasonography and coronary angiography | NAFLD is associated with CAD and need for coronary intervention, but not increased mortality or cardiovascular complications. |
| Idilman [74] | 2015 | 273 | Abdominal and cardiac computed tomography | NAFLD is associated with significant CAD in type 2 diabetic patients. |
| Puchner [75] | 2014 | 445 | Abdominal and cardiac computed tomography | NAFLD is associated with advanced high-risk coronary plaque. |
| Wong [76] | 2011 | 612 | Abdominal ultrasonography and coronary angiography | NAFLD is associated with CAD independently of other metabolic factors. |
| Sun [77] | 2011 | 542 | Abdominal and cardiac computed tomography | NAFLD is associated with high severity of CAD, requiring consciousness in patients with abdominal obesity. |
| Açikel [78] | 2009 | 355 | Abdominal ultrasonography and coronary angiography | NAFLD is associated with the presence of CAD and severity of coronary atherosclerosis. |
Abbreviations: CAD: coronary artery disease, NAFLD: non-alcoholic fatty liver disease, CVD: cardiovascular disease.