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. 2024 Oct 3;25(19):10649. doi: 10.3390/ijms251910649

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Plasma LPC levels are strongly associated with sensorimotor dysfunction. (A,B) At 24 h post-MCAO induction, rats show significant sensorimotor and proprioceptive impairments, which are exacerbated by LPC(18:1) supplementation and mitigated by LPC formation inhibition. (C,D) Plasma LPC(18:1) and LPC(16:0) levels demonstrate moderate correlations with sensorimotor outcomes. (E,F) Brain LPC(18:1) and LPC(16:0) levels show strong correlations with sensorimotor outcomes. (n = 6, * p < 0.05, **** p < 0.0001, Bar graphs: black circles = sham, red triangles = LPC+, blue open circles = LPC−, Correlation graphs: black circles = Plasma LPC, open circles = Brain LPC).