Figure 2.

Unique clusters identified in endothelial cells (EC). (A) A total of 16,766 cells were identified as ECs and were clustered into eight main subsets as seen in the UMAP. These included venous EC, pre-venular capillaries, capillary EC, post-capillary venules, arterial EC, lymphatic EC, pericytes/EC and proliferating EC. (B) Dot plot representing the three main identifying genes for each subcluster of EC. (C) Most EC subclusters had a higher proportion of LS cells, except for pericytes/EC. (D) Volcano plot of dysregulated genes in the overall endothelial cell subset compared with healthy endothelial cells, with attention to XIST and PECAM1 (circled) as significantly upregulated in LS endothelial cells.