Table A2.

Univariable and multivariable median regression models for postoperative maximum NT-proBNP concentrations.

Variable	Comparison	Estimated Effect	Lower 95% CL	Upper 95% CL	p-Value
Univariable median regression analysis
Randomization group	Sevoflurane vs. Desflurane	56.292	−43.716	156.300	0.271
Age		27.600	13.646	41.554	<0.001
BMI		−0.073	−7.862	6.316	0.831
Sex	Male vs. Female	−35.961	−125.105	53.184	0.43
ASA	III vs. I–II	143.000	−57.748	343.748	0.164
Baseline NT-proBNP		1.101	0.444	1.759	<0.001
Duration of anesthesia		1.222	−0.131	2.575	0.078
Type of surgery
	Urologic vs. General	68.026	−88.270	224.322	0.395
	Gynecologic vs. General	131.938	−28.675	292.551	0.109
	Gynecologic vs. Urologic	63.912	−43.352	171.175	0.244
Intraoperative MAP		6.237	−0.516	12.991	0.072
Beta-blocker	Yes vs. No	282.844	77.135	488.554	0.008
Ca2+ channel blocker	Yes vs. No	23.319	−98.258	144.896	0.707
Aspirin	Yes vs. No	−8.257	−194.771	178.257	0.931
Statin	Yes vs. No	20.000	−100.271	140.271	0.745
Xa inhibitor	Yes vs. No	549.024	193.549	904.499	0.003
ACE inhibitor	Yes vs. No	77.854	−61.885	217.593	0.276
Hypertension	Yes vs. No	70.461	−62.878	203.800	0.302
Myocardial infarction	Yes vs. No	213.847	−267.607	695.302	0.385
Diabetes II	Yes vs. No	72.683	−156.233	301.600	0.535
Multivariable median regression analysis
Age		2.326	−7.423	12.075	0.641
Baseline NT-proBNP		1.047	0.076	2.017	0.036
Beta-blocker	Yes vs. No	29.127	−93.321	151.576	0.642
Xa inhibitor	Yes vs. No	−18.641	−185.280	148.358	0.829

CL, confidence limit; BMI, body mass index; ASA, American Society of Anesthesiologists physical status; MAP, mean arterial pressure; ACE, angiotensin converting enzyme.