Skip to main content
. 2024 Oct 7;29(19):4737. doi: 10.3390/molecules29194737

Figure 2.

Figure 2

(A) Schematic image of gene silencing with siRNA or miR mimic. The siRNA and miR mimic are incorporated within the RISC in the cytoplasm and then unwind, activating the guide strands. (B) Schematic image of gene silencing with RNase H-mediated cleavage with ASO. ASOs with chemically modified sugar backbones inhibit mRNA expression through steric hindrance. (C) Schematic image of gene silencing with CNA-based cleavage. The presence of metal ions helps to stabilize the activated structure of ribozymes and is essential for the catalytic activity of DNAzymes.