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Anti-cancer therapeutic strategies using aptamer-based protein inhibition. (A) Schematic image of multimeric aptamer for EpCAM and PDGF protein inhibition. (B) Schematic image of bispecific aptamer for lysosomal degradation of target membrane proteins with IGFIIR-mediated lysosomal proteolysis systems. (C) Schematic image of bispecific aptamer for target membrane receptor inhibition by thrombin-mediated cleavage. (Adapted from Refs. [134,138,139]).
