Table 3.

Prediction performance of five radiomics models (Tumor, External2, External5, Tumor + External2, and Tumor + External5) in three cohorts

Model	Cohort	AUC [95% CI]	Accuracy	Sensitivity	Specificity	PPV	NPV
Tumor	Training	0.975 [0.963-0.987]	0.963	0.957	0.969	0.969	0.958
	Internal-testing	0.800 [0.769-0.831]	0.791	0.871	0.576	0.847	0.625
	External-testing	0.741 [0.686-0.796]	0.716	0.743	0.642	0.852	0.473
External2	Training	0.949 [0.937-0.961]	0.897	0.873	0.921	0.917	0.879
	Internal-testing	0.779 [0.750-0.809]	0.739	0.828	0.500	0.816	0.520
	External-testing	0.612 [0.551-0.673]	0.679	0.794	0.357	0.775	0.384
External5	Training	0.947 [0.932-0.961]	0.879	0.909	0.849	0.857	0.903
	Internal-testing	0.765 [0.737-0.794]	0.729	0.800	0.538	0.823	0.500
	External-testing	0.625 [0.562-0.688]	0.679	0.743	0.500	0.805	0.411
Tumor + External2	Training	0.971 [0.962-0.981]	0.954	0.927	0.981	0.980	0.931
	Internal-testing	0.827 [0.799-0.855]	0.822	0.871	0.692	0.884	0.666
	External-testing	0.745 [0.699-0.791]	0.773	0.794	0.714	0.885	0.555
Tumor + External5	Training	0.968 [0.958-0.979]	0.936	0.903	0.969	0.967	0.909
	Internal-testing	0.818 [0.794-0.843]	0.770	0.828	0.615	0.852	0.571
	External-testing	0.742 [0.699-0.785]	0.773	0.820	0.642	0.864	0.562