Figure 3.

Functional and molecular characteristics of ICBT signatures. Blue represent IRS, yellow for IGS, red for IAS. In the PPI network, each node is an independent protein, and the lines represent the interaction between the nodes. The size of a node is determined by the number of edges connected to the node. The position of a node is determined by the distance between the node and all the interacting nodes around it, meaning that proteins in the network tend to interact with neighboring proteins. ICBT, immune checkpoint blockade therapy; IRS, ICBT RNA regulatory signature; IGS, ICBT genomic stability signature; IAS, ICBT angiogenesis signature; PPI, Protein-protein interaction.