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. 2024 Sep 15;14(9):4337–4352. doi: 10.62347/KCPN6689

Figure 1.

Figure 1

NR4A2 plays an important role in pancreatic cancer cell survival and migration. A. Expression of NR4A2 in PDAC patient’s tissues as compared to that in normal pancreas tissues, *P<0.05 (data extracted from TCGA database). B. MiaPaCa2 and Panc1 cell proliferation after RNA silencing of NR4A2 (siNR4A2) and overexpression of NR4A2 (NOE) compared with controls (siCTRL and EV) was determined over time. C. Western blot and RT-qPCR analysis for NR4A2 expression in MiaPaCa2 and Panc1 cells after NR4A2 overexpression or knockdown. D. MiaPaCa2 and Panc1 cell images (4× magnification) and quantification of invaded cell numbers in Boyden chamber assay. E. MiaPaCa2 cell migration Images (4× magnification) and quantification of migrated cells in the scratch assay after NR4A1 knockdown or overexpression (NOE) in MiaPaCa2 cells. Quantitated results are means ± SE for at least 3 replicate determinations; significance, *P<0.05, **P<0.01, ***P<0.001.