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The correlation between the dysregulation of other signaling pathways and lenvatinib resistance. The dysregulation of lipid metabolism, wnt/β-catenin signaling, hippo signaling, notch signaling, hedgehog signaling, RNA modifications and ferroptosis was found to participate the regulation of LEN resistance in uHCC treatment. And, a series of proteins and a range of drugs acted on corresponding targets to play roles in promoting or inhibiting LEN resistance in HCC treatment.
