Figure 3.

The correlation between the dysregulation of non-coding RNAs (ncRNAs) and lenvatinib resistance. The dysregulation of non-coding RNA, including lncRNA, circRNA and microRNA, was demonstrated to be closely related to LEN resistance in uHCC. A series of lincRNA and circRNA, as ceRNAs, regulated downstream mRNA expression by competitively binding with miRNA, thus involving in regulation of LEN resistance. In addition, ncRNAs participated in regulating associated signaling pathways, including MAPK/ERK, AKT, hippo, autophagy, NF-κB and FGFR4 signaling, which promoted or inhibited LEN resistance in HCC treatment. Solid lines represent the role in promoting LEN resistance, and dashed lines represent the role in suppressing LEN resistance in uHCC treatment. Pointed arrows represent activating effects, and blunt arrows represent inhibitory effect. The same is true for arrows and lines described below.