Table 2.

The correlation between associated drugs and lenvatinib resistance in uHCC treatment

Drug name	Drug types	Roles	LEN resistance	Reference
Elacridar	ABCB1 and BCRP inhibitor	Inhibition of ABCB1 and BCRP	Inhibition	[354]
Flubendazole	Anthelmintic	Inhibition of PCSK9 and hedgehog signaling	Inhibition	[276]
Losartan	AT-II receptor blocker	Suppressing VEGF-A expression	Inhibition	[348]
Secukinumab	Biologic agent targeting IL-17A	Inhibition of BCL2 expression and promotion of autophagy pathway	Inhibition	[231]
Palbociclib	CDK4/6 inhibitor	Inhibition of wnt/β-catenin signaling	Inhibition	[257]
Abemaciclib	Chinese herbal extracts	Inhibition of c-MYC	Inhibition	[350]
Amentoflavone		Inhibition of AKT/ERK signaling	Inhibition	[183]
Sophoridine		Inhibition of VEGFR2 and MAPK/ERK signaling	Inhibition	[185]
OSC		Inhibition of FGFR1, AKT/mTOR and MAPK/ERK signaling	Inhibition	[187]
Betulin		Inhibition of the mTOR/IL-1β signaling	Inhibition	[240]
CP		Inhibition of exosome-mediated autophagy	Inhibition	[233]
Curcumin		Inhibition of EGFR and PI3K/AKT signaling	Inhibition	[207]
Dasatinib	c-SRC inhibitor	Inhibition of c-SRC	Inhibition	[351]
Erlotinib	EGFR inhibitor	Inhibit of STAT/ABCB1 axis and inhibition of LEN exocytosis	Inhibition	[355]
GANT61	GLI1/2 inhibitor	Inhibition of hedgehog signaling	Inhibition	[273]
Simvastatin	HMG CoA Reductase inhibitor	Inhibition of cholesterol synthesis and hedgehog signaling	Inhibition	[282]
Metformin	Hypoglycemic drug	Inhibition of AKT signaling	Inhibition	[203]
Metformin		Inhibition of wnt/β-catenin signaling	Inhibition	[256]
BAFA1	Macrolide antibiotics	Inhibit autophagic degradation of NRP1	Promotion	[222]
Aspirin	NSAIDs	Downregulation of AKT and MAPK/ERK signaling	Inhibition	[357]
Celecoxib		Decrease the survival rate of PD-L1 neutrophils	Inhibition	[358]
Vitamin C	Vitamins	/	Inhibition	[349]

Abbreviations: ABCB1: ATP binding cassette subfamily B member 1; BCRP: Breast cancer resistance protein; PCSK9: Proprotein convertase subtilisin/kexin type 9; BCL2: B-cell lymphoma 2; OSC: Oxysophocarpine; CP: Compound phyllanthus urinaria; BAFA1: Bafilomycin A1; NSAIDs: Non-steroidal anti-inflammatory drugs.