Table 2.

Comparison of IC₅₀ of various plant extracts against triple negative breast cancer cell lines

Plant name	Extraction methods	Model	Pathway	IC50	Reference
Citrus hystrix	Hexane	MDA-MB-231	Induces apoptosis	317.6 μg/mL	[72]
Annona cherimmola	Ethanol	MDA-MB-231	Induces apoptosis	555.3 μg/mL	[73]
Holothuria scabra	95% ethanol	MDA-MB-231	Regulate Akt/mTOR/HIF-1 axis	11.8 μg/mL	[74]
Garcinia quaesita	Hexane	bCSCs	Induces apoptosis	57.5 μg/mL	[75]
Origanum syriacum	80% ethanol	MDA-MB-231	Induces apoptosis	875 μg/mL	[76]
Antenoron Filiforme	Ethanol	MDA-MB-231, MDA-MB-453	Skp2/p21	149.7 μg/mL in MDA-MB-231, 34.26 μg/mL in MDA-MMB-453	[77]
		BALB/c
Ziziphus nummularia	Ethanol	MDA-MB-231	Induce autophagy and apoptosis	662.4 μg/mL	[78]
Ruellia tuberosa	Methanol	MDA-MB-231, 4T1	Induces apoptosis	23.8 μg/mL	[79]
		BALB/c mouse
Lespedeza bicolor	Ethanol	BT549, MDA-MB-231, and MDA-MB-468	Regulate FAK pathways	MDA-MB-468, MDA-MB-231, and BT549 were 32.83 μg/mL, 29.4 μg/mL, and 20.28 μg/mL, respectively	Present study
		Balb/c mouse