Table 1.

Classification and therapeutic applications of RTKs

Receptor family	Receptor	Applications
Epidermal growth factor receptor, EGFR	HER1, HER2, HER3, HER4	Non-small cell lung cancer, head and neck tumors, colorectal cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer
Insulin receptor, INSR	IGF-I, IGF-II, INSR, INSRR	Breast cancer, hematological malignancies, colorectal cancer, lung cancer, cervical cancer
Platelet-derived growth factor receptor, PDGFR	PDGFRα, PDGFRβ, CSF-1R, SCFR, FLK2, FLT3	Hypereosinophilic syndrome, mastocytosis, gastrointestinal stromal tumor, epithelial cell tumor, leukemia
Fibroblast growth factor receptor, FGFR	FGFR1, FGFR2, FGFR3, FGFR4	Angiogenesis
Vascular endothelial growth factor receptor, VEGFR	VEGFR1, VEGFR2, VEGFR3, VEGFR4	Hepatocellular carcinoma, lung cancer, ovarian cancer
Hepatocyte growth factor receptor, HGFR	HGFR, MSPR	Breast cancer, colorectal cancer, gastric cancer, prostate cancer, renal cell carcinoma
Angiopoietins receptor of Tie family	Tie1, Tie2, TEK	Hemangioblastoma, epithelial cell tumor, gastric cancer, hepatocellular carcinoma