Table 1.
Ototoxic chemotherapeutic drugs and their incidence of symptoms
| Drug name | Cisplatin | Carboplatin | Vinblastine | Vincristine | Dasatinib | isotretinoin | Tretinoin | |
|---|---|---|---|---|---|---|---|---|
| Drug Class | Alkylating agent | Plant alkaloid | Vinca alkaloid | Tyrosine kinase inhibitor | Retinoid | Retinoid | ||
| Antineoplastic Mechanism | DNA binding and cross-linking | microtubule inhibitor | Src kinase inhibitor | microtubule inhibitor | ||||
| Protein cross-linking | ||||||||
| Ototoxic Mechanism | ROS overload, proinflammatory cytokine production | Possible synergy with other drugs | Unclear. Possibly associated with their antitumor activity | |||||
| Incidence rate | Hearing loss | 31% | 12% | 10-29% | No data | 0.1-1% | No data | 6% |
| Tinnitus | 31% | 12% | No data | No data | 1-10% | No data | No data | |
| Dizziness | No data | No data | Rare | No data | 1-10% | No data | 20% | |
| Vertigo | No data | No data | Rare | No data | 0.1-1% | No data | No data | |