Table 2.
Recurrent targeted genes and relationship with tumors
| Gene symbol | Band | Integrated times | Cancer related | Summary | Reference (PMID) |
|---|---|---|---|---|---|
| Y_RNA | 15q22, 3q22, 4q22, 5q31, 1p13, 3p22, 22q12 | 8 | N | - | - |
| snoU13 | 7p15, 1q42, 6p22, 5q23, 1p34, 9q22 | 6 | N | - | - |
| AL162151.3 | 14q32 | 4 | N | - | - |
| RPL3P4 | 14q32 | 4 | N | - | - |
| IKZF2 | 2q34 | 3 | Y | Functions pivotally in T-cell differentiation and activation. | NCBI gene/Ref (23600753) |
| RP11-105N14.1 | 2q34 | 3 | N | - | - |
| RP11-105N14.3 | 2q34 | 3 | N | - | - |
| U3 | 8p21, 6q21, Xq25 | 3 | Y | Non-conventional regulatory functions of U3 (or fragments derived from it) in mRNA metabolism. | NCBI gene/Ref (27517747) |
| IFNG-AS1 | 12q15 | 2 | Y | Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. | NCBI gene/Ref (28600289) |
| IL26 | 12q15 | 2 | Y | The encoded protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. | NCBI gene/Ref (23704922) |
| RORA | 15q22 | 2 | Y | The encoded protein has been shown to interact with NM23-1, the product of a tumor metastasis suppressor candidate gene. | NCBI gene/Ref (22104449) |
| CDH18 | 5p14 | 2 | Y | - | - |
| LINC00970 | 1q24 | 2 | N | - | - |
| RPL29P7 | 1q24 | 2 | N | - | - |
| SUMO1P2 | 1q24 | 2 | N | - | - |
| EXOC4 | 7q33 | 2 | Y | The encoded protein is found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. | NCBI gene/Ref (23207790) |
| CREB5 | 7p15 | 2 | Y | This gene binds to the cAMP response element and activates transcription. | UniProt/Ref (25076032) |
| AC005105.2 | 7p15 | 2 | N | - | - |
| THSD7A | 7p21 | 2 | Y | The encoded protein appears to interact with integrin αVβ3 and paxillin to inhibit endothelial cell migration and tube formation. | NCBI gene/Ref (28035718) |
| RP11-457M11.2 | 6p22 | 2 | N | - | - |
| VN1R14P | 6p22 | 2 | N | - | - |
| ZNF322 | 6p22 | 2 | Y | The gene may regulate transcriptional activation in MAPK signaling pathways. | NCBI gene/Ref (15555580) |
| CADM2 | 3p12 | 2 | Y | Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. | UniProt/Ref (23643812) |
| GRM1 | 6q24 | 2 | Y | This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. | NCBI gene/Ref (27458247) |
| AC005592.2 | 5q31 | 2 | N | - | - |
| CA8 | 8q12 | 2 | Y | Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. | NCBI gene/Ref (26711783) |
| AC005027.3 | 7p14 | 2 | N | - | - |
| AHRR | 5p15 | 2 | Y | The protein encoded by this gene is involved in regulation of cell growth and differentiation. | NCBI gene/Ref (16755028) |
| PDCD6 | 5p15 | 2 | Y | May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. | NCBI gene/Ref (25362542) |
Abbreviations: Y: Yes; means that these genes had been reported to be tumor-related based on NCBI database; N: no; means that there was no report about the relationship between this gene and tumors.