Table 3.
Correlation between serum d–ROMs levels and biomarkers or questionnaires in BA, COPD and ACO.
| BA | COPD | ACO | ||||
|---|---|---|---|---|---|---|
| rs | p | rs | p | rs | p | |
| Age | 0.275 | 0.004 | 0.028 | 0.829 | 0.241 | 0.124 |
| pack-years | −0.171 | 0.076 | −0.057 | 0.659 | −0.076 | 0.633 |
| WBC | 0.253 | 0.008 | 0.265 | 0.036 | 0.023 | 0.884 |
| Neutrophils | 0.293 | 0.002 | 0.265 | 0.036 | 0.257 | 0.100 |
| Eosinophils | −0.123 | 0.204 | 0.431 | <0.001 | −0.003 | 0.835 |
| IgE | 0.061 | 0.526 | −0.020 | 0.879 | 0.145 | 0.360 |
| CRP | 0.375 | <0.001 | 0.431 | <0.001 | 0.440 | 0.004 |
| SAA | 0.316 | 0.001 | 0.408 | 0.001 | 0.487 | 0.001 |
| IL-6 | 0.270 | 0.004 | 0.487 | <0.001 | 0.483 | 0.001 |
| IL-8 | 0.232 | 0.015 | 0.118 | 0.358 | 0147 | 0.352 |
| TNF-α | −0.038 | 0.691 | 0.035 | 0.787 | 0.417 | 0.006 |
| FeNO | 0.011 | 0.912 | −0.160 | 0.212 | −0.039 | 0.808 |
| ACT Score | −0.388 | <0.001 | NA | NA | −0.280 | 0.072 |
| CAT Score | NA | NA | 0.442 | <0.001 | 0.329 | 0.034 |
| SGRQ Score | 0.391 | <0.001 | 0.406 | 0.001 | 0.440 | 0.004 |
d–ROMs, derivatives–reactive oxygen metabolites; BA, bronchial asthma; COPD, chronic obstructive pulmonary disease; ACO, asthma–COPD overlap; WBC, white blood cells; IgE, immunoglobulin E; CRP, C-reactive protein; SAA, serum amyloid A; IL, interleukin; TNF-α, tumor necrosis factor alpha; FeNO, fractional exhaled nitric oxide; ACT, asthma control test; CAT, COPD assessment test; SGRQ, St. George’s Respiratory Questionnaire; NA, not available.