Table 1.

Evolving convergent RRV and BFV mutations with statistical support.

Gene	Nucleotide positionsa	Amino acid position in genea	Convergentamino acid mutationb	Mean number of amino acid mutations at codon site	Mean rate of amino acid change	Bayes factor of transition ratec	Posterior probability	Median jumpsd	Lower (2.5%)–Upper (97.5%) credible intervale
RRV
nsP1	821–823	248f	T to I	37.100	0.999	Inf	1.0	21	14–26
nsP1	1400–1402	441f	K to E	7.014	1.759	4827.2	1.0	4	3–7
E3	8554–8556	59	G to R	3.745	1.483	54.0	1.0	2	0–3
E2	9736–9738	389	A to T	2.184	1.357	Inf	1.0	2	2–3
E1	10 354–10 356	113	I to V	5.069	1.270	Inf	1.0	3	2–7
BFV
nsP1	951–953	297f	K to E	5.964	1.930	2658.794	1.0	3	2–5
nsP1	1400–1402	447f	S to G	4.122	1.091	Inf	1.0	4	4–5
nsP4	5772–5774	103	V to A	2.208	1.108	Inf	1.0	2	1–3
E3	8146–8148	21	G to D	3.635	1.127	Inf	1.0	2	1–5
E3	8254–8256	57	T to M	3.575	1.139	80.018	0.980	1	0–2
E2	8359–8361	24	T to A	2.161	1.097	Inf	1.0	2	2–3
E2	9129–9131	281	A to V	2.521	1.452	Inf	1.0	2	1–4

^aNucleotide and aa sequence positions are numbered according to the prototype viruses, isolate T48 (GenBank accession number GQ433359) for RRV and isolate BH2193 (GenBank accession number U73745.1) for BFV.

^bConvergent aa mutations repeatedly observed in phylogenetic trees (Fig. 1).

^cBayes factor statistical support (>3.2) for aa transition; Inf (infinity) was observed when the entire posterior included this rate as a parameter, such that the posterior odds were infinity and therefore also the Bayes factor.

^dPosterior median number of transition events (Markov jumps) for aa substitution.

^eUpper and lower bounds of the credible interval of the number of jumps.

^fConvergent mutations evolving under significant positive selection.