Table 5.

Hierarchy of Recommended Oral Antibiotics for EOS by Silo (ie Susceptibility of S. aureus)

Silo	Recommended Oral Antibiotic According to Allocated Backbone Domain
	Adult		Pregnancy		Pediatric
PSSA	Benzylpenicillin	(Flu)cloxacillin	Benzylpenicillin	(Flu)cloxacillin	Benzylpenicillin	(Flu)cloxacillin
	Amoxicillin (Flu/di)cloxacillin Cefalexin/cefadroxil Linezolid	(Flu/di)cloxacillin Amoxicillin Cefalexin/cefadroxil Linezolid	Amoxicillin (Flu/di)cloxacillin Cefalexin/cefadroxil	(Flu/di)cloxacillin Amoxicillin Cefalexin/cefadroxil	Amoxicillin Cefalexin/cefadroxil (Flu/di)cloxacillin Linezolid	Cefalexin/cefadroxil (Flu/di)cloxacillin Amoxicillin Linezolid
MSSA	(Flu)cloxacillin	Cefazolin	(Flu)cloxacillin	Cefazolin	(Flu)cloxacillin	Cefazolin
	(Flu/di)cloxacillin Cefalexin/cefadroxil Linezolid	Cefalexin/cefadroxil (Flu/di)cloxacillin Linezolid	(Flu/di)cloxacillin Cefalexin/cefadroxil	Cefalexin/cefadroxil (Flu/di)cloxacillin	Cefalexin/cefadroxil (Flu/di)cloxacillin Linezolid	Cefalexin/cefadroxil (Flu/di)cloxacillin Linezolid
MRSA	Vancomycin/daptomycin	Vancomycin/daptomycin + cefazolin	Vancomycin/daptomycin	Vancomycin/daptomycin + cefazolin	Vancomycin/daptomycin	Vancomycin/daptomycin + cefazolin
	Linezolid Fluoroquinolone + rifampicin TMP-SMX Fusidic acid + rifampicin	Linezolid Fluoroquinolone + rifampicin TMP-SMX Fusidic acid + rifampicin	Clindamycin TMP-SMXa	Clindamycin TMP-SMXa	TMP-SMX Linezolid Fluoroquinolone + rifampicin Fusidic acid + rifampicin	TMP-SMX Linezolid Fluoroquinolone + rifampicin Fusidic acid + rifampicin

Site PIs and treating clinicians are encouraged, but not mandated, to select the highest antibiotic on this list which is appropriate for a given patient.

Abbreviations: EOS, early oral switch; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin- susceptible Staphylococcus aureus; PSSA, penicillin-susceptible Staphylococcus aureus; TMP-SMX, trimethoprim-sulfamethoxazole.

^aTMP-SMX only suitable during the second trimester. Avoid in first and third trimester.