Table 2.
Characteristics of 137 RTRs according to obesity phenotypes 1.
| MHNO (n = 77) | MHO (n = 11) | MANO (n = 33) | MAO (n = 16) | p for Trend | |
|---|---|---|---|---|---|
| Demographics | |||||
| Male/female | 45/32 | 8/3 | 15/18 | 12/6 | 0.173 |
| Age, year | 48.09 ± 12.77 | 51.18 ± 7.24 | 53.21 ± 11.27 | 44.94 ± 14.51 | 0.102 |
| Height, cm | 161.39 ± 8.17 | 162.55 ± 8.70 | 161.56 ± 8.73 | 164.69 ± 9.77 | 0.554 |
| Body weight, kg | 57.22 ± 9.93 a | 76.26 ± 8.80 b | 62.90 ± 8.34 a | 80.13 ± 12.07 b | <0.0001 |
| Body mass index, kg/m2 | 21.87 ± 2.62 a | 28.78 ± 1.16 c | 24.07 ± 2.21 b | 29.37 ± 1.83 c | <0.0001 |
| WC, cm | 79.09 ± 7.77 a | 92.65 ± 7.41 b | 85.64 ± 7.16 a | 96.47 ± 5.04 b | <0.0001 |
| Renal transplant time, year | 7.43 ± 6.84 | 12.97 ± 5.36 | 9.38 ± 8.17 | 7.42 ± 4.81 | 0.066 |
| Tacrolimus/cyclosporine used $ | 51/21 | 6/5 | 18/14 | 14/2 | 0.113 |
| Deceased/living donors | 53/24 | 8/3 | 25/8 | 10/6 | 0.797 |
| Laboratory | |||||
| Albumin, g/dL | 4.34 ± 0.30 a | 4.03 ± 0.34 b | 4.34 ± 0.21 a | 4.36 ± 0.40 c | 0.016 |
| Blood urea nitrogen, mg/dL | 23.54 ± 9.28 | 24.48 ± 7.23 | 26.15 ± 13.86 | 21.90 ± 8.37 | 0.532 |
| Creatinine, mg/dL | 1.35 ± 0.57 | 1.39 ± 0.54 | 1.57 ± 1.00 | 1.49 ± 0.58 | 0.482 |
| AC-sugar, mg/dL | 89.71 ± 11.85 a | 93.73 ± 11.45 a | 114.06 ± 22.97 a | 125.19 ± 74.42 b | <0.0001 |
| HbA1c, % | 5.72 ± 0.50 a | 6.07 ± 0.46 b | 6.60 ± 1.07 b | 6.43 ± 1.05 b | <0.0001 |
| Uric acid, mg/dL | 6.25 ± 1.26 | 6.34 ± 1.20 | 5.61 ± 1.30 | 6.36 ± 1.24 | 0.074 |
| Total cholesterol, mg/dL | 205.62 ± 46.61 | 201.55 ± 43.34 | 214.91 ± 45.57 | 204.38 ± 50.44 | 0.751 |
| Triglycerides, mg/dL | 110.92 ± 45.99 | 134.45 ± 68.69 | 241.52 ± 176.38 | 257.31 ± 168.58 | <0.0001 |
| HDL-C, mg/dL | 59.79 ± 16.93 a | 52.45 ± 14.11 b | 44.75 ± 13.93 b | 45.31 ± 14.73 b | <0.0001 |
| LDL-C, mg/dL | 120.11 ± 38.97 | 119.82 ± 32.17 | 122.33 ± 36.13 | 114.44 ± 40.00 | 0.925 |
| AST, U/L | 23.57 ± 6.72 | 26.64 ± 8.12 | 27.30 ± 8.71 | 27.81 ± 9.52 | 0.048 |
| ALT, U/L | 19.65 ± 12.72 | 27.36 ± 20.03 | 27.24 ± 23.42 | 32.50 ± 20.79 | 0.021 |
| Insulin, mU/L | 5.96 ± 2.93 a | 9.83 ± 4.37 a | 11.24 ± 17.90 a | 58.16 ± 136.69 b | 0.002 |
| hs-CRP, mg/dL | 3.42 ± 4.18 | 6.40 ± 7.96 | 12.21 ± 27.52 | 5.38 ± 7.64 | 0.042 |
| Others | |||||
| Energy, kcal/day | 1849.23 ± 371.76 | 1955.94 ± 382.84 | 1733.8 ± 385.04 | 1685.81 ± 529.46 | 0.175 |
| eGFR, mL/min/1.73 m2 | 57.75 ± 20.41 | 57.09 ± 20.80 | 50.03 ± 21.49 | 54.69 ± 17.19 | 0.336 |
| SBP, mmHg | 130.13 ± 15.53 | 133.91 ± 13.14 | 138.43 ± 16.09 | 143.03 ± 18.34 | 0.008 |
| DBP, mmHg | 75.94 ± 11.83 | 76.29 ± 6.98 | 80.64 ± 13.35 | 81.28 ± 11.99 | 0.160 |
| CCI | 1.87 ± 1.18 | 2.00 ± 1.55 | 2.39 ± 0.97 | 1.88 ± 1.09 | 0.180 |
| HOMA-IR | 1.41 ± 1.11 a | 2.37 ± 1.14 a | 2.38 ± 1.34 a | 15.88 ± 39.03 b | 0.003 |
| HSI | 29.50 ± 4.55 a | 38.08 ± 5.44 b | 33.61 ± 5.23 a | 39.86 ± 4.13 b | <0.0001 |
Abbreviations: RTRs, renal transplant recipients; MHNO, metabolically healthy nonobese; MHO, metabolically healthy obese; MANO, metabolically abnormal nonobese; MAO, metabolically abnormal obese; WC, waist circumference; AC-sugar, preprandial blood glucose; HbAlC, glycated hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; hs-CRP, high-sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; CCI, Charlson comorbidity index; HOMA-IR, homeostasis model assessment-insulin resistance; HSI, hepatic steatosis index. 1 Values are presented as the mean ± standard deviation or number, as appropriate. Statistical analyses were conducted using analysis of variance (ANOVA), and p values refer to the overall ANOVA among the four groups. Post hoc analyses were performed using Scheffe’s adjustment for multiple comparisons. Category means not accompanied by the same letter symbol are significantly different from each other. $ No records of six patients.