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. 2024 Sep 19;16(10):2322–2348. doi: 10.1038/s44321-024-00140-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV5 — (A) Principal component analysis (PCA) showcasing the global variation within and between groups for the overall samples. (B) Scatter plot of orthogonal projections to latent structures-discriminant analysis (OPLS-DA) illustrating the differences between groups. (C, D) Volcano plot demonstrating the differential metabolites after 2 and 3 h of normothermic machine perfusion (NMP). (E) Heatmap displaying the z-score distribution of significantly different metabolites across various time points, with each row representing a metabolite. The heatmap was generated with the DESeq2 R package. (A–E) n = 5 pigs in each group, triplicate perfusate samples for technical replicates in each pig. (C, D) P values were calculated by the Wald test using the DESeq2 R package.