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. 2001 Mar;75(5):2130–2141. doi: 10.1128/JVI.75.5.2130-2141.2001

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Copyright © 2001, American Society for Microbiology

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FIG. 9 — Antibody titer against HVR1 epitopes in mouse sera taken at different time points, shown as a function of time. Mice were immunized on days 0, 33, and 47 (indicated by arrows), and the serum was taken on days 0 (prebleed), 47, 56, 69, 82, 110, 143, and 209 (A1, B1 and C), or mice were immunized on days 0 and 15 and serum was taken on days 0 (prebleed), 24, 44, and 57 (A2 and B2). Antibody titers against the HVR1-1a epitope in two mice immunized with HBsAg/Age-35-1a (A1 and A2), against HVR1-1b in one mouse immunized with HBsAg/Age-36-1b (B1 and B2), and in three mice immunized with a combination of particles (C). ○, antibody titer against the HVR1-1a epitope; ●, antibody titer against the HVR1-1b epitope. The titer is given as the arimethic mean, and the bars indicate the range of antibody titers obtained. The values shown in panels A2, B2, and C indicate titers outside the range of the y axis.

FIG. 9 — Antibody titer against HVR1 epitopes in mouse sera taken at different time points, shown as a function of time. Mice were immunized on days 0, 33, and 47 (indicated by arrows), and the serum was taken on days 0 (prebleed), 47, 56, 69, 82, 110, 143, and 209 (A1, B1 and C), or mice were immunized on days 0 and 15 and serum was taken on days 0 (prebleed), 24, 44, and 57 (A2 and B2). Antibody titers against the HVR1-1a epitope in two mice immunized with HBsAg/Age-35-1a (A1 and A2), against HVR1-1b in one mouse immunized with HBsAg/Age-36-1b (B1 and B2), and in three mice immunized with a combination of particles (C). ○, antibody titer against the HVR1-1a epitope; ●, antibody titer against the HVR1-1b epitope. The titer is given as the arimethic mean, and the bars indicate the range of antibody titers obtained. The values shown in panels A2, B2, and C indicate titers outside the range of the y axis.