Table 3.

OA-thyrotoxicosis MR analysis for outliers, heterogeneity, and pleiotropy of genetic instruments.

Exposure	Outcome	Method	P-Global test	P-heterogeneity	Egger intercept	P-intercept
Knee OA	Autoimmune hyperthyroidism	IVW		0.960
		MR Egger		0.986	0.056	0.655
		MR-PRESSO	0.944
	Thyrotoxicosis	IVW		0.679
		MR Egger		0.976	0.077	0.243
		MR-PRESSO	0.603
	Thyrotoxicosis with diffuse goitre	IVW		0.808
		MR Egger		0.769	0.048	0.541
		MR-PRESSO	0.833
	Thyrotoxicosis	IVW		0.767
		MR Egger		0.966	0.077	0.299
		MR-PRESSO	0.719
Hip OA	Autoimmune hyperthyroidism	IVW		0.881
		MR Egger		0.893	0.051	0.310
		MR-PRESSO	0.871
	Thyrotoxicosis	IVW		0.222
		MR Egger		0.233	-0.024	0.293
		MR-PRESSO	0.229
	Thyrotoxicosis with diffuse goitre	IVW		0.466
		MR Egger		0.449	-0.022	0.405
		MR-PRESSO	0.444
	Thyrotoxicosis	IVW		0.131
		MR Egger		0.133	-0.025	0.353
		MR-PRESSO	0.129

The heterogeneity test in the IVW methods was performed using Cochran’s Q statistic and the global test for the MR-PRESSO method. P < 0.05 was considered significant. OA, osteoarthritis; IVW, inverse variance weighted; P-heterogeneity, P value for heterogeneity test; P-intercept, P value for the intercept of MR-Egger regression.