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. 2024 May 28;31(10):1580–1588. doi: 10.1038/s41594-024-01323-5

Fig. 1. Cryo-EM structure of the XPD complex in the presence of a Y-forked DNA substrate containing an engineered cross-link.

Fig. 1

a, Schematic description of sample preparation prior to vitrification. b, Cryo-EM map of the class 1 XPD–p44–DNA complex. XPD is colored in green, p44 is colored in cyan and DNA is colored in orange. c, Left, structural model of the XPD–p44–DNA complex in cartoon representation, color-coded as in b. Right, Rotation (180°) of the model around its y axis. d, Cryo-EM map of the class 2 XPD–p44–DNA complex, color-coded as in b. e, Close-up of the dsDNA–ssDNA junction and the cross-link at the Arch domain of XPD, color-coded as in b. The cross-link is shown as spheres.