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. 2024 May 28;31(10):1580–1588. doi: 10.1038/s41594-024-01323-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — The figure shows possible lesion recognition strategies for non canonical and canonical NER lesions. Upper panel: When XPD encounters a non canonical crosslink no lesion locking occurs and XPD backtracking can take place. Backtracking pulls XPG across the lesion enabling cutting 5′ to the lesion. Lower panel: canonical lesion encounter enables XPD lesion locking and XPG cutting 3′ to the damage as observed in regular NER.